Resource Type

Journal Article 218

Conference Videos 4

Year

2024 1

2023 16

2022 32

2021 22

2020 21

2019 22

2018 17

2017 5

2016 8

2015 12

2014 8

2013 7

2012 6

2011 2

2010 6

2009 6

2008 11

2007 10

2006 1

2005 1

open ︾

Keywords

resistance 12

Antibiotic resistance genes 10

drug resistance 8

Antibiotic resistance 6

insulin resistance 6

Escherichia coli 3

Antibiotic resistance genes (ARGs) 3

Antibiotic resistance gene 2

Antibiotics 2

Antimicrobial resistance 2

Chlorination 2

Metagenomics 2

Resistome 2

Sulfonamide resistance genes 2

Wheat 2

antibiotic resistance 2

antimicrobial activity 2

breeding 2

cancer 2

open ︾

Search scope:

排序： Display mode:

Association between the Phenotypes and Genotypes of Antimicrobial Resistance in Haemophilus parasuis Article

Chao Nguyen Van, Lijun Zhang, Tam Vu Thi Thanh, Hung Pham Hoang Son, Tuan Tran Ngoc, Qi Huang, Rui Zhou

Engineering 2020, Volume 6, Issue 1,   Pages 40-48 doi: 10.1016/j.eng.2019.10.014

Abstract: One of the reasons why the control of H. parasuis has failed is the increase in antimicrobial resistanceThe tested strains were shown to have a high frequency of resistance to trimethoprim/sulfamethoxazole(94.6%), followed by resistance to colistin, chloramphenicol, gentamicin, penicillin, lincomycin, and

Keywords： Haemophilus parasuis     Antimicrobial resistance     Antimicrobial resistance gene     Vietnam    

HTML PDF Collect

Advances in Antimicrobial Resistance Editorial

Jiangzhong Shen, Timothy R. Walsh

Engineering 2022, Volume 15, Issue 8,   Pages 1-2 doi: 10.1016/j.eng.2022.06.003

HTML PDF Collect

Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical

Ying Ma,Nanxue Zhang,Shi Wu,Haihui Huang,Yanpei Cao

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 517-521 doi: 10.1007/s11684-016-0480-9

Abstract:

This study aimed to compare the antimicrobial activities of topical agents against PropionibacteriumThe resistance rates to neomycin sulfate, erythromycin, and clindamycin were 11.7%, 49.3%, and 33.4%,The high resistance rate to clindamycin and erythromycin was significantly affected by gender, previous

Keywords： antimicrobial susceptibility/resistance     Propionibacterium acnes     topical antibiotics     in vitro study    

HTML PDF Collect

Antimicrobial Resistance Exchange Between Humans and Animals: Why We Need to Know More Views & Comments

Julian Parkhill

Engineering 2022, Volume 15, Issue 8,   Pages 11-12 doi: 10.1016/j.eng.2022.04.007

HTML PDF Collect

Antimicrobial use in food animal production: situation analysis and contributing factors

Ziping WU

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3,   Pages 301-311 doi: 10.15302/J-FASE-2018207

Abstract: which antimicrobials are used, and reviewing different technical and socioeconomic factors influencing antimicrobialuse at farm level, this study discusses the main knowledge gaps in antimicrobial use in food animalThe review reveals that antimicrobial use in food animals exhibit strong regional and species differences, and there are still large information gaps concerning the current state of antimicrobial use.Factors associated with animal health (including antimicrobial resistance), animal health improvement

Keywords： antimicrobial use     drivers for antimicrobial use     food animal production    

HTML PDF Collect

Discovery of novel ursolic acid derivatives as effective antimicrobial agents through a ROS-mediated

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 2101-2113 doi: 10.1007/s11705-023-2361-5

Abstract: The antimicrobial mechanism showed that compound A17 induced an excessive accumulationOverall, we developed the promising antimicrobial agents that destroyed the redox system of phytopathogenic

Keywords： ursolic acid     antibacterial activities     reactive oxygen species     apoptosis    

HTML PDF Collect

of copper nanoparticles on multiwalled carbon nanotubes modified with poly (acrylic acid) and their antimicrobial

Li SHENG,Shuhang HUANG,Minghao SUI,Lingdian ZHANG,Lei SHE,Yong CHEN

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 4,   Pages 625-633 doi: 10.1007/s11783-014-0711-8

Abstract: viability determination and fluorescence imaging results demonstrated that Cu-PAA/MWCNTs possessed strong antimicrobialThe deposited Cu was suggested to play an important role in the antimicrobial action of Cu-PAA/MWCNTs

Keywords： multiwalled carbon nanotubes     copper nanoparticles     antimicrobial activity     Escherichia coli (    

HTML PDF Collect

Microwave-assisted synthesis and antimicrobial activities of 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin

Hua CHEN, Yanan LI, Jie BAI, Lian ZHAO, Xiangguo YUAN, Xiaoliu LI, Keqiang CAO

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 2,   Pages 186-191 doi: 10.1007/s11705-009-0004-0

Abstract: The antimicrobial activities of the compounds against pv. lachrymans (Smith et Bryan) Young, Dye &

Keywords： microwave-assisted synthesis     naphthyl     thiazolidin-4-one     antimicrobial    

HTML PDF Collect

Conjugation with Acridines Turns Nuclear Localization Sequence into Highly Active Antimicrobial Peptide Artical

Wei Zhang,Xiaoli Yang,Jingjing Song,Xin Zheng,Jianbo Chen,Panpan Ma,Bangzhi Zhang,Rui Wang

Engineering 2015, Volume 1, Issue 4,   Pages 500-505 doi: 10.15302/J-ENG-2015106

Abstract: In this study, we synthesized a novel type of antimicrobial agent, Acr3-NLS, by conjugatingTo further improve the antimicrobial activity of our agent, dimeric (Acr3-NLS)2show that Acr3-NLS and especially (Acr3-NLS)2 display significant antimicrobialtargets–cell membrane and intracellular DNA–will reduce the risk of bacteria developing resistanceOverall, this study provides a novel strategy to design highly effective antimicrobial agents with a

Keywords： acridine     nuclear localization sequence     conjugate     antimicrobial activity     mechanism of action    

HTML PDF Collect

Transmission of Carbapenem Resistance Between Human and Animal NDM-Positive Escherichia coli Strains Article

Yingbo Shen, Fupin Hu, Yongqiang Wang, Dandan Yin, Lu Yang, Yiqiang Chen, Chunyan Xu, Jiyun Li, Junyao Jiang, Xueyang Wang, Yulin Fu, Dongyan Shao, Dejun Liu, Tengfei Ma, Chang Cai, Zhangqi Shen, Shaolin Wang, Juan Li, Rong Zhang, Yuebin Ke, Congming Wu, Jianzhong Shen, Timothy R. Walsh, Yang Wang

Engineering 2022, Volume 15, Issue 8,   Pages 24-33 doi: 10.1016/j.eng.2021.07.030

Abstract:

Although carbapenem use is prohibited in animals in China, carbapenem-resistant Escherichia coli (CREC), especially New Delhi metallo-β-lactamase (NDM)-producing strains, are widely prevalent in foodproducing animals. At present, the impact of livestock-associated CREC strains on human populations at the national level is unknown. Here, we conduct a retrospective cross-sectional study to investigate the prevalence of CREC from clinical settings across 22 Chinese provinces or municipalities and analyze anthropogenic factors associated with their presence. We also ascertain the blaNDM and blaKPC abundance among pig and chicken farms and present a detailed genomic framework for CREC of animal and human origin. Overall, 631/29799 (2.1%) clinical Escherichia coli (E. coli) isolates were identified as CREC. Multivariable analysis revealed that being male, an age below 1, an age between 13 and 18, provinces with greater chicken production, and provinces with higher pig production were associated with higher odds of CREC infection. In general, 73.8% (n = 45/61) of pig farms and 62.2% (n = 28/45) of chicken farms had a blaNDM abundance of 1×10－5 to 1×10－3 and 1×10－3  to 1×10－2, respectively. Among all the Chinese NDM-positive E. coli (n = 463) available at the National Center for Biotechnology Information (NCBI), the genomic analysis revealed that blaNDM-5 and IncX3 were the predominant carbapenemase gene-plasmid combination, while a highly homogeneous relationship between NDM-positive isolates from humans and animals was demonstrated at the plasmid and core genome levels. All the findings suggest frequent CREC transmission between humans and animals, indicating that further discussions on the use of antibiotics in animals and humans are needed, both in China and across the globe.

Keywords： Carbapenem resistance     Escherichia coli     blaNDM-5     One Health     Antimicrobialresistance transmission    

HTML PDF Collect

Prevalence of antifolate drug resistance markers in in China

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 83-92 doi: 10.1007/s11684-021-0894-x

Abstract: dhfr) and dihydropteroate synthetase (dhps) genes of Plasmodium vivax and antifolate resistance-associatedgenes were used for drug resistance surveillance.This study indicated that the antifolate resistance levels of P. vivax parasites were differentacross China and molecular markers could be used to rapidly monitor drug resistance.

Keywords： drug resistance     antifolates     molecular markers     Plasmodium vivax     China    

HTML PDF Collect

Metagenomic analysis on resistance genes in water and microplastics from a mariculture system

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 1,   Pages 4-4 doi: 10.1007/s11783-021-1438-y

Abstract: Mariculture systems have been observed to host microplastics and antibiotic resistance genes (ARGs).However, more information on proliferation of ARGs and metal resistance genes (MRGs) in mariculture system

Keywords： Antibiotic resistance genes     Metal resistance genes     Metagenomic analysis     Microplastics     Mariculture    

HTML PDF Collect

Strategies on designing multifunctional surfaces to prevent biofilm formation? ?

Yang Lu,Zhanguo Yue,Wei Wang,Zhiqiang Cao

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 3,   Pages 324-335 doi: 10.1007/s11705-015-1529-z

Abstract: Bacteria adhesion and biofilm formation have raised severe problems on public health, food industry and many other areas. A variety of reagents and surface coatings have been developed to kill bacteria and/or limit their interaction with surfaces. It has also attracted many efforts to integrate different bactericidal elements together and maximize antibacterial efficiency. Herein, we review mechanisms for both passive and active approaches to resist and kill bacteria respectively, and discuss integrated strategies based on these two approaches. We also offer perspective on future research direction.

Keywords： antimicrobial     surface     multifunctional    

HTML PDF Collect

Multifunctional antimicrobial chlorhexidine polymers by remote plasma assisted vacuum deposition

Ana Mora-Boza, Francisco J. Aparicio, María Alcaire, Carmen López-Santos, Juan P. Espinós, Daniel Torres-Lagares, Ana Borrás, Angel Barranco

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 2,   Pages 330-339 doi: 10.1007/s11705-019-1803-6

Abstract: Novel antibacterial materials for implants and medical instruments are essential to develop practical strategies to stop the spread of healthcare associated infections. This study presents the synthesis of multifunctional antibacterial nanocoatings on polydimethylsiloxane (PDMS) by remote plasma assisted deposition of sublimated chlorhexidine powders at low pressure and room temperature. The obtained materials present effective antibacterial activity against K12, either by contact killing and antibacterial adhesion or by biocide agents release depending on the synthetic parameters. In addition, these multifunctional coatings allow the endure hydrophilization of the hydrophobic PDMS surface, thereby improving their biocompatibility. Importantly, cell-viability tests conducted on these materials also prove their non-cytotoxicity, opening a way for the integration of this type of functional plasma films in biomedical devices.

Keywords： plasma polymers     conformal plasma deposition     chlorhexidine     bactericide     PDMS     biocompatibility    

HTML PDF Collect

Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 490-495 doi: 10.1007/s11684-018-0647-7

Abstract: While most cancer therapies are given in combinations that are designed to avoid drug resistance, wetherapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drug resistanceThis approach is based on notion that drug resistance comes at a fitness cost to the cancer cell that

Keywords： cancer     drug resistance     genetic screens     senescence     targeted therapy    

HTML PDF Collect

Title Author Date Type Operation

Association between the Phenotypes and Genotypes of Antimicrobial Resistance in Haemophilus parasuis

Chao Nguyen Van, Lijun Zhang, Tam Vu Thi Thanh, Hung Pham Hoang Son, Tuan Tran Ngoc, Qi Huang, Rui Zhou

Journal Article

Advances in Antimicrobial Resistance

Jiangzhong Shen, Timothy R. Walsh

Journal Article

Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical

Ying Ma,Nanxue Zhang,Shi Wu,Haihui Huang,Yanpei Cao

Journal Article

Antimicrobial Resistance Exchange Between Humans and Animals: Why We Need to Know More

Julian Parkhill

Journal Article

Antimicrobial use in food animal production: situation analysis and contributing factors

Ziping WU

Journal Article

Discovery of novel ursolic acid derivatives as effective antimicrobial agents through a ROS-mediated

Journal Article

of copper nanoparticles on multiwalled carbon nanotubes modified with poly (acrylic acid) and their antimicrobial

Li SHENG,Shuhang HUANG,Minghao SUI,Lingdian ZHANG,Lei SHE,Yong CHEN

Journal Article

Microwave-assisted synthesis and antimicrobial activities of 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin

Hua CHEN, Yanan LI, Jie BAI, Lian ZHAO, Xiangguo YUAN, Xiaoliu LI, Keqiang CAO

Journal Article

Conjugation with Acridines Turns Nuclear Localization Sequence into Highly Active Antimicrobial Peptide

Wei Zhang,Xiaoli Yang,Jingjing Song,Xin Zheng,Jianbo Chen,Panpan Ma,Bangzhi Zhang,Rui Wang

Journal Article

Transmission of Carbapenem Resistance Between Human and Animal NDM-Positive Escherichia coli Strains

Yingbo Shen, Fupin Hu, Yongqiang Wang, Dandan Yin, Lu Yang, Yiqiang Chen, Chunyan Xu, Jiyun Li, Junyao Jiang, Xueyang Wang, Yulin Fu, Dongyan Shao, Dejun Liu, Tengfei Ma, Chang Cai, Zhangqi Shen, Shaolin Wang, Juan Li, Rong Zhang, Yuebin Ke, Congming Wu, Jianzhong Shen, Timothy R. Walsh, Yang Wang

Journal Article

Prevalence of antifolate drug resistance markers in in China

Journal Article

Metagenomic analysis on resistance genes in water and microplastics from a mariculture system

Journal Article

Strategies on designing multifunctional surfaces to prevent biofilm formation? ?

Yang Lu,Zhanguo Yue,Wei Wang,Zhiqiang Cao

Journal Article

Multifunctional antimicrobial chlorhexidine polymers by remote plasma assisted vacuum deposition

Ana Mora-Boza, Francisco J. Aparicio, María Alcaire, Carmen López-Santos, Juan P. Espinós, Daniel Torres-Lagares, Ana Borrás, Angel Barranco

Journal Article

Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Journal Article